Beilstein J. Org. Chem.2019,15, 2840–2846, doi:10.3762/bjoc.15.277
observed in acidic ethanol in the presence of an amine, which provided the corresponding dihydropyrrolonederivative as the major reaction product. Based on this transformation, a practical and convenient one-pot synthetic method for substituted pyrrolo[3,4-b]pyridin-5-ones could be devised.
Keywords
: condensation; dihydropyrrolonederivative; one-pot synthesis; pyrrolo[3,4-b]pyridine-4,5-diones; recyclization; Introduction
Derivatives of pyrrolo[3,4-b]pyridin-5-one are known for their broad-spectrum biological activity [1][2][3]. One example includes a family of compounds based on this fragment that was